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| c. 1000 |
| | | The first illustrated manual of surgery is written by Abul Kasim, an Arab physician in Cordoba | |
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| c. 1040 |
| | | A Chinese manual on warfare includes the earliest known description of gunpowder | |
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| 1054 |
| | | Astronomers in China and Japan observe the explosion of the supernova which is still visible as the Crab Nebula | |
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| 1066 |
| | | Halley's comet, appearing in the Normans' annus mirabilis, is later depicted in the Bayeux tapestry | |
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| c. 1480 |
| | | Leonardo da Vinci takes a professional interest in the new science of fortification | |
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| c. 1489 |
| | | Leonardo da Vinci begins an unprecedented series of detailed anatomical drawings, based on corpses dissected in Rome | |
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| c. 1500 |
| | | Leonardo argues that fossils in rocks far above the sea imply not the effects of the Flood but a change in the level of an ancient sea bed | |
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| 1530 |
| | | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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| 1543 |
| | | Polish astronomer Nicolaus Copernicus publishes a book suggesting that the earth moves round the sun | |
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| 1543 |
| | | Flemish anatomist Andreas Vesalius publishes a seven-volume work which for the first time lays bare human anatomy | |
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